Related Experiment Video
Updated: Sep 30, 2026

Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion
Published on: March 18, 2014
[The biological effect of matrix metalloproteinase-1 in epidermal repair]
1Department of Burns, Xijing Hospital, Fourth Military Medical University, Xi'an Shanxi, P. R. China 710032. hudahai@fmmu.edu.cn
Objective:
To review the role of matrix metalloproteinase-1 (MMP-1) in the course of healing in wounded skin.
Methods:
The recent literatures on MMP-1 in skin wound repair were reviewed, which gave the insight into the local effect of MMP-1 during re-epithelialization.
Results:
Following injury, basal keratinocytes, moving from the wound edge and interact with dermal matrix proteins in the wound bed, were induced to express MMP-1 in a specific space-time pattern. MMP-1 cleaved the collagen, thereby altering its structure and affinity by which the keratinocytes binded it. MMP-1 served a beneficial role in wound healing by facilitating the proliferation and movement of keratinocytes over the collagen-rich wound bed during re-epithelialization.
Conclusion:
MMP-1 expression of migrating keratinocytes directly influences the re-epithelialization during the course of healing of the wounded skin.
Related Concept Videos
The Extracellular Matrix
The Extracellular Matrix
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
Role of Matrix Metalloproteases in Degradation of ECM
A...
Cell-matrix's Response to Mechanical Forces
Anchoring junctions mechanically attach a cell to the...
Clinical Applications of Epidermal Stem Cells
Phases of Wound Repair
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...

