Electrical modification of disuse osteoporosis

Localized electrical stimulation of the immobilized hind limb of young rabbits resulted in dramatically more bone in the tuber calcis (heel bone) compared to the severe loss of bone (osteoporosis) seen in unstimulated, immobilized controls. Detailed histological evaluation using microradiography and fluorescence and polarization microscopy showed that the increase was probably due to an overall inhibition of surface cortical bone loss )endosteal resorption) and an increase in the quantity of the new immature bone. There was also evidence of increased osteonal resorption in the stimulated animals.