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Updated: Oct 5, 2026

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
Published on: July 16, 2014
Activation of spinal serotonin(2A/2C) receptors augments nociceptive responses in the rat
A Kjørsvik1, A Tjølsen, K Hole
1Department of Physiology and Locus on Neuroscience, University of Bergen, Arstadveien 19, N-5009, Bergen, Norway. anne.kjoersvik@haukeland.no
Abstract:
The role of spinal 5-HT(2A/2C) receptors in the regulation of spinal nociceptive transmission was studied. The 5-HT(2A/2C) agonist (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and the antagonist ketanserin tartrate were administered intrathecally immediately before the formalin test. Activation of spinal 5-HT(2A/2C) receptors increased the pain-like behavioural response in both the early and late phases. The findings support the hypothesis that spinal 5-HT(2A/2C) receptors augment the spinal afferent nociceptive impulses induced by peripheral inflammation.
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