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Tumor immunity and immunotherapy
P Boura1, J Kountouras, N J Lygidakis
1Department of Medicine, Second Medical Clinic, Aristotelian University of Thessaloniki, Thessaloniki, Greece. Boura@med.auth.gr
Recent advances in understanding fundamental mechanisms of regulation of the immune response are throwing light into mechanisms of tumor growth. The understanding of the immunological aspects of tumor expansion is leading to the development of new strategies to stimulate the immune system to mount more effective responses to tumors. This progress as well as some promising results in clinical trials is generating considerable optimism. The goal of this review is to present recent advances concerning tumor immunology, identify some of the pitfalls and problems that still exist and present new areas of immunotherapy that look promising.
Recent advances in understanding fundamental mechanisms of regulation of the immune response are throwing light into mechanisms of tumor growth. The understanding of the immunological aspects of tumor expansion is leading to the development of new strategies to stimulate the immune system to mount more effective responses to tumors. This progress as well as some promising results in clinical trials is generating considerable optimism. The goal of this review is to present recent advances concerning tumor immunology, identify some of the pitfalls and problems that still exist and present new areas of immunotherapy that look promising.