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The structure of physalin T from Physalis alkekengi var. franchetti
M Kawai1, T Yamamoto, B Makino
1Department of Applied Chemistry, Nagoya Institute of Technology, Japan. kawai@ach.nitech.ac.jp
Journal of Asian Natural Products Research
|August 9, 2001
Abstract:
A new steroidal constituent named physalin T (3) was isolated from the aqueous extract of Physalis alkekengi var. francheti. Based on 1H and 13C NMR spectral studies the structure was assigned as 2,3-dihydrophysalin D, i.e., 5alpha,6beta-dihydroxy-2,3,5,6-tetrahydrophysalin B, which is the first example of a natural physalin possessing a saturated ring A moiety. The structure was confirmed by the chemical transformation from the known physalin D (2) to physalin T.