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Subcutaneous hemangiosarcomas in a rhesus macaque (Macaca mulatta)
D D Myers1, R C Dysko, C E Chrisp
1Unit for Laboratory Animal Medicine, The University of Michigan, Ann Arbor 48109-0614, USA. ddmyers@umich.edu
Journal of Medical Primatology
|August 9, 2001
Summary
This study documents a rare case of hemangiosarcoma, a vascular tumor, in a rhesus monkey. Diagnostic tests confirmed the presence of hemangiosarcoma in two abdominal masses.
Area of Science:
- Veterinary Pathology
- Oncology
- Primate Medicine
Background:
- Hemangiosarcoma is a rare vascular endothelial malignancy.
- Documented cases in nonhuman primates are exceptionally infrequent.
- Understanding its occurrence in nonhuman primates aids comparative oncology.
Observation:
- An adult male rhesus monkey presented with a subcutaneous abdominal mass.
- A second, similar mass developed weeks later.
- Initial fine-needle aspirate showed erythrocytes and inflammatory cells.
Findings:
- Histopathology revealed spindle-shaped cells around vascular spaces, indicative of malignancy.
- Immunohistochemistry confirmed tumor cells expressed Factor VIII-related antigen.
- Both masses were diagnosed as hemangiosarcoma.
Implications:
- This case expands the known spectrum of hemangiosarcoma in nonhuman primates.
- It highlights the importance of diagnostic procedures for identifying rare tumors in research animals.
- Further research may elucidate risk factors and treatment strategies for primate hemangiosarcoma.
