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Published on: June 12, 2019

Rosuvastatin reduced deep vein thrombosis in ApoE gene deleted mice with hyperlipidemia through non-lipid lowering

K A Patterson1, X Zhang, S K Wrobleski

  • 1Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, MI 48103, USA.

Thrombosis Research
|January 2, 2013
PubMed
Abstract

Insights

Rosuvastatin effectively reduced venous thrombosis in hyperlipidemic mice by inhibiting inflammation and neutrophil migration, independent of its lipid-lowering effects. This study highlights rosuvastatin

Area of Science:

  • Pharmacology
  • Thrombosis Research
  • Cardiovascular Science

Background:

  • Statins, specifically rosuvastatin, are gaining attention for their role in managing venous thrombosis.
  • Hyperlipidemia is a known risk factor for developing venous thrombosis.
  • Understanding non-lipid-lowering effects of statins is crucial for optimizing treatment strategies.

Purpose of the Study:

  • To investigate the non-lipid-lowering effects of rosuvastatin on venous thrombosis.
  • To evaluate rosuvastatin's impact on thrombosis in a mouse model of hyperlipidemia.

Main Methods:

  • Utilized an inferior vena cava ligation model to induce venous thrombosis in hyperlipidemic mice.
  • Administered rosuvastatin (5mg/kg) or saline via gavage 48 hours prior to thrombosis induction.
  • Assessed thrombus weight, inflammatory markers, plasminogen activator inhibitor-1 (PAI-1) levels, and neutrophil migration.

Main Results:

  • Rosuvastatin significantly reduced thrombus weight.
  • Decreased expression and plasma levels of plasminogen activator inhibitor-1 (PAI-1).
  • Inhibited neutrophil migration into the vein wall and reduced expression of interleukin-6 pathway molecules.

Conclusions:

  • Rosuvastatin demonstrates beneficial effects in mitigating venous thrombosis in hyperlipidemic mice.
  • These protective effects are attributed to rosuvastatin's non-lipid-lowering mechanisms.
  • Supports the therapeutic potential of rosuvastatin beyond cholesterol reduction in thrombosis management.

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