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Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay (EMSA) and DNA-affinity Precipitation Assay (DAPA)
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Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay (EMSA) and DNA-affinity Precipitation Assay (DAPA)

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Microsatellite polymorphism of the MICA gene and susceptibility to rheumatoid arthritis

D P Singal1, J Li, G Zhang

  • 1Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada. singald@fhs.csu.mcmaster.ca

Clinical and Experimental Rheumatology
|August 9, 2001
PubMed

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Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...