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Related Experiment Videos

Risk factors for sudden unexpected death among workers: a nested case-control study in central Japan.

H Kondo1, T Kawamura, M Hirai

  • 1First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan.

Preventive Medicine
|August 9, 2001
PubMed
Summary

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Sudden death risk factors in apparently healthy male workers were identified. Periodic medical checkups can help predict and prevent these events.

Area of Science:

  • Occupational Health
  • Cardiovascular Epidemiology
  • Preventive Medicine

Background:

  • Limited research exists on sudden death in apparently healthy workers.
  • Risk factors for sudden cardiac death (SCD) in this demographic remain underexplored.

Purpose of the Study:

  • To identify risk factors for sudden death among apparently healthy male employees.
  • To assess the predictive value of routine medical checkups for sudden death.

Main Methods:

  • A nested case-control study involving 164,017 male employees in Japan.
  • Comparison of medical data from 242 sudden death victims with 505 matched controls.
  • Logistic regression analysis to calculate odds ratios (ORs) and 95% confidence intervals (CIs).

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Main Results:

  • Elevated blood pressure, hypo-HDL-cholesterolemia, hyperuricemia, abnormal liver enzymes, and urinary findings were associated with increased risk.
  • Electrocardiogram (ECG) abnormalities (arrhythmias, ST-T changes, Q waves) significantly increased sudden death risk (ORs 3.5-4.8).
  • Hypertension, proteinuria, glucosuria, arrhythmias, ST-T abnormalities, and light drinking emerged as independent predictors in multivariate analysis.

Conclusions:

  • Periodic medical checkups are valuable for identifying individuals at risk of sudden death.
  • These findings underscore the importance of comprehensive health assessments in the workplace for preventive strategies.
  • Modifiable risk factors identified can inform targeted interventions to reduce employee sudden death rates.