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Related Experiment Videos

Epithelial Phenotype in Ewing's Sarcoma/Primitive Neuroectodermal Tumor.

Funda Vakar-López1, Alberto G. Ayala, A. Kevin Raymond

  • 1Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas.

International Journal of Surgical Pathology
|August 9, 2001
PubMed
Summary

Ewing's sarcoma/primitive neuroectodermal tumors (PNET) often show neural features but can also express keratins, indicating focal epithelial differentiation. This finding is common in typical PNETs and can aid diagnosis.

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Area of Science:

  • Oncology
  • Pathology
  • Molecular Biology

Background:

  • Ewing's sarcoma/primitive neuroectodermal tumor (PNET) is characterized by neural differentiation.
  • Epithelial differentiation in PNET is uncommon but can complicate diagnosis.

Purpose of the Study:

  • To investigate the frequency of epithelial differentiation in Ewing's sarcoma/PNET.
  • To assess the coexpression of neural and epithelial markers.

Main Methods:

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded tissues from 33 Ewing's sarcoma/PNET cases.
  • Utilized antikeratin antibodies to detect epithelial differentiation.
  • Assessed expression of neural markers (neuron-specific enolase, synaptophysin) and MIC-2 gene product.

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Main Results:

  • Focal keratin positivity observed in 18% of cases; diffuse coexpression in two cases.
  • MIC-2 gene product expressed in 94% of tumors.
  • Primitive neural phenotype detected in 30% (NSE) or 15% (both NSE and synaptophysin).

Conclusions:

  • Ewing's sarcoma/PNET frequently exhibits focal keratin expression alongside neural differentiation.
  • Focal epithelial phenotype is a relatively common finding in typical Ewing's sarcoma/PNET.
  • These findings can assist in the differential diagnosis of PNET.