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Updated: Jan 7, 2026

A Novel and Translational Rat Model of Concussion Combining Force and Rotation with In Vivo Cerebral Microdialysis
Published on: July 12, 2019
New treatments for concussion: the next millennium beckons
1Centre for Sports Medicine Research & Education, and Brain Research Institute, University of Melbourne, Australia. pmccrory@compuserve.com
Abstract:
As increased understanding of the pathophysiology of mild traumatic brain injury and concussion develops, so the scientific rationale for interventional pharmacological therapy becomes paramount. A number of agents have been postulated or have been the subject of anecdotal noncontrolled trials. This paper reviews the published evidence in this regard. To date no effective pharmacological therapy exists that satisfies Class I evidence-based medicine criteria.

