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High-resolution structures and dynamics of membrane protein--lipid complexes: a critique
E Pebay-Peyroula1, J P Rosenbusch
1IBS, UMR 5075 CEA-CNRS-UJF, F-38027 Grenoble Cedex 1, France. pebay@ibs.fr
Current Opinion in Structural Biology
|August 10, 2001
Abstract:
Crystallographic analysis of lipidic components in complex with membrane proteins reveals molecules exhibiting well-ordered polar or hydrophobic moieties in contact with protein. As dynamic methods indicate high exchange rates, the interpretation of structural data requires a detailed knowledge of the specificity, affinity and cooperativity of lipid binding.