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Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
Published on: January 16, 2019
Functional analysis of pathogenicity genes in a genomics world
1Delaware Technology Park, Suite 200, 1 Innovation Way, PO 6104, Newark, Delaware 19714-6104, USA. jim.sweigard@usa.dupont.com
Current Opinion in Microbiology
|August 10, 2001
Summary
Genome-wide analyses in yeast offer a model for studying gene function in filamentous fungi. This research aids in understanding pathogenicity genes, particularly with the Neurospora crassa genome resource.
Area of Science:
- Fungal Genomics
- Molecular Mycology
Background:
- Yeast serves as a model organism for large-scale genomic analyses.
- Filamentous fungi, including plant pathogens, require advanced genetic study methods.
Purpose of the Study:
- To establish a model for large-scale gene function analysis in filamentous fungi using yeast.
- To leverage the Neurospora crassa genome for comparative studies with plant pathogenic fungi.
- To advance molecular genetic studies of pathogenicity genes.
Main Methods:
- Genome-wide mutational analyses in yeast.
- Genome-wide expression analyses in yeast.
Main Results:
- Development of a yeast-based model applicable to filamentous fungi.
- Identification of potential targets for pathogenicity gene research.
Conclusions:
- Genome-wide analyses in yeast provide a robust model for filamentous fungi.
- The Neurospora crassa genome facilitates comparative genomics for plant pathogenic fungi.
- These approaches are crucial for dissecting fungal pathogenicity mechanisms.
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