[Estrogen therapy in climacteric. Current views in an evidence-based perspective]

In Sweden, approximately 65,000 women enter menopause each year. Hormone replacement therapy (HRT) for the treatment of climacteric symptoms is well documented, but the role of HRT in the prevention of other diseases is more questionable. The existing literature is discussed from an evidence-based perspective. There is strong evidence supporting the treatment of subjective symptoms, and also a scientific basis for long term treatment of women at increased risk of osteoporosis. Few studies address the issue as to how HRT should be prescribed and followed-up. It is important to consider the issue of quality of life in times of limited resources.