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Single-unit neural recording with active microelectrode arrays.

Q Bai1, K D Wise

  • 1Engineering Research Laboratory, Agilent Technologies, Inc, Palo Alto, CA 94304-1126, USA.

IEEE Transactions on Bio-Medical Engineering
|August 14, 2001
PubMed
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On-chip signal processing in microelectrode arrays minimally impacts neural recording noise. This technology enables high-fidelity in vivo recordings from single neurons with advanced circuitry.

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Electrical Engineering

Background:

  • Microelectrode arrays are crucial for neural recording.
  • On-chip signal processing offers potential for improved neural interfaces.
  • Minimizing noise is critical for accurate single-unit activity detection.

Purpose of the Study:

  • To characterize the performance of microelectrode arrays with integrated signal processing circuitry.
  • To evaluate the impact of on-chip components on neural recording quality.
  • To demonstrate low-noise in vivo recordings using advanced probe designs.

Main Methods:

  • Utilized microelectrode arrays with on-chip unity-gain operational amplifiers and closed-loop preamplifiers.
  • Performed simultaneous in vivo recordings comparing buffered and unbuffered (passive) iridium sites.

Related Experiment Videos

  • Evaluated input DC-baseline stabilization techniques.
  • Demonstrated low-noise recordings with a multiplexed probe using an external asymmetrical clock.

    • Main Results:

    • Buffered probes exhibited an output resistance of 200 ohm and input-referred noise of 11-muV rms (100 Hz-10 kHz).
    • On-chip circuitry did not significantly degrade system noise compared to passive sites.
    • Closed-loop preamplifiers achieved a voltage gain of 40 dB and 13 kHz bandwidth.
    • The multiplexed probe added less than 8-muV rms noise, suppressing clock transitions to <2 ppm.

    Conclusions:

    • On-chip signal processing is viable for neural recording microelectrode arrays without significant noise increase.
    • Integrated circuitry, including preamplifiers and stabilization techniques, facilitates high-quality in vivo neural recordings.
    • Multiplexed probes with external clocking represent a significant advancement for low-noise neural signal acquisition.