Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Toxicity Testing in Animals01:23

Toxicity Testing in Animals

68
Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
68
Sampling Methods: Sample Types01:18

Sampling Methods: Sample Types

3.4K
Sampling materials are classified into three main types: solid, liquid, and gas.
Solid samples include a variety of substances, such as sediments from water bodies, soil, metals, and biological tissues. Two standard methods for extracting sediments from water bodies are grab sampling and piston coring. Grab sampling involves using a device to collect a discrete sediment sample from the bottom of a water body with minimal disturbance. Grab samples do not always represent the entire area due to...
3.4K
Drug Concentrations: Measurements01:23

Drug Concentrations: Measurements

1.2K
Drug concentration is the quantity of a drug present in a biological sample. Measuring drug amounts in biological samples allows the clinician to understand how a drug is absorbed, distributed, metabolized, and excreted. Samples can be obtained through invasive or non-invasive methods. Invasive techniques involve surgical or parenteral interventions to gather blood, cerebrospinal fluid, or tissue biopsy. Conversely, non-invasive approaches provide samples like urine, feces, and saliva.
Plasma...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Commonly Practiced Quality Control and Quality Assurance Procedures for Gas Chromatography-Mass Spectrometry Analysis in Forensic Urine Drug-Testing Laboratories.

Forensic science review·2015
Same author

The evolution of substantial equivalence in FDA's premarket review of medical devices.

Food and drug law journal·2002
Same author

Rapid detection of benzoylecgonine in vitreous humor by enzyme immunoassay.

Journal of analytical toxicology·2001
Same author

Detection of cocaine and its metabolites in breast milk.

Journal of forensic sciences·2001
Same author

The disposition of cocaine and opiate analytes in hair and fingernails of humans following cocaine and codeine administration.

Journal of analytical toxicology·2000
Same author

The characterization of human urine for specimen validity determination in workplace drug testing: a review.

Journal of analytical toxicology·2000
Same journal

Is drug facilitated sexual assault changing? About a case involving 4-bromomethcathinone.

Journal of analytical toxicology·2026
Same journal

Differentiation of 2-, 3-, and 4-Fluorofuranylfentanyl Using HPLC-MS and Human Liver Microsomes.

Journal of analytical toxicology·2026
Same journal

Trends and Circumstances of Pediatric Fentanyl Deaths in North Carolina: A 10-year Retrospective Study.

Journal of analytical toxicology·2026
Same journal

Drug Detection in Traffic-Related Fatalities in Connecticut (2020-2024).

Journal of analytical toxicology·2026
Same journal

Characterization of postmortem γ-hydroxybutyric acid (GHB) and a novel model to discern exogenous use.

Journal of analytical toxicology·2026
Same journal

Development and validation of a quantitative analytical method for urine samples in drug-facilitated sexual assault cases.

Journal of analytical toxicology·2026
See all related articles

Related Experiment Video

Updated: Mar 4, 2026

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs
10:13

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs

Published on: November 8, 2024

2.9K

Alternative specimens for workplace drug testing.

Y H Caplan1, B A Goldberger

  • 1National Scientific Services, Baltimore, Maryland 21208, USA.

Journal of Analytical Toxicology
|August 14, 2001
PubMed
Summary
This summary is machine-generated.

Workplace drug testing now uses alternative specimens like saliva, hair, and sweat. These methods offer valuable insights into drug use patterns and are becoming standard in forensic toxicology.

More Related Videos

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
10:17

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

10.4K
Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones
06:06

Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones

Published on: February 5, 2018

26.9K

Related Experiment Videos

Last Updated: Mar 4, 2026

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs
10:13

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs

Published on: November 8, 2024

2.9K
High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
10:17

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

10.4K
Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones
06:06

Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones

Published on: February 5, 2018

26.9K

Area of Science:

  • Forensic toxicology
  • Analytical chemistry
  • Occupational health

Background:

  • Workplace drug testing traditionally relies on urine analysis.
  • Advances in analytical techniques allow for drug and metabolite detection in alternative biological samples.
  • Various alternative specimens provide distinct information on drug use history.

Purpose of the Study:

  • To evaluate the utility of alternative biological specimens for workplace drug testing.
  • To assess the role of oral fluid, hair, and sweat in forensic toxicology.
  • To understand the expanding capabilities in detecting drug use patterns.

Main Methods:

  • Analysis of drugs and drug metabolites.
  • Detection in alternative biological specimens including oral fluid (saliva), hair, and sweat.
  • Evaluation for federally regulated workplace testing programs.

Main Results:

  • Detection of drugs and metabolites is feasible in alternative specimens.
  • Oral fluid, hair, and sweat are identified as key alternative matrices.
  • Ongoing evaluation by the Department of Health and Human Services is determining program utility.

Conclusions:

  • Alternative specimens enhance the understanding of drug use patterns.
  • Testing of alternative specimens is expected to become routine in forensic toxicology.
  • These methods expand the scope and effectiveness of workplace drug testing programs.