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Dialysis-related amyloidosis
1Department of Radiology, The Jikei University School of Medicine, 3--25--8 Nishi-shimbashi, Minato-ku, Tokyo, 105--8461, Japan.
Abstract:
Dialysis-related amyloidosis (DRA) is a well-recognized complication in patients on long-term hemodialysis. It occurs secondary to the deposition of beta(2)-microglobulin, preferentially in the musculoskeletal tissues. Plain radiography demonstrates advanced DRA findings such as bone erosions and cystic lesions, but it is not suitable for the demonstration of earlier changes. Magnetic resonance imaging and ultrasound are sufficient for the detection of amyloid deposition in the periarticular soft tissues and in the evaluation of spinal complications.
Insights
Dialysis-related amyloidosis (DRA) is a complication of long-term hemodialysis caused by beta(2)-microglobulin deposition. Advanced imaging like MRI and ultrasound can detect soft tissue and spinal changes in DRA.
Area of Science:
- Nephrology
- Radiology
- Biomedical Engineering
Background:
- Dialysis-related amyloidosis (DRA) is a known complication in patients undergoing long-term hemodialysis.
- It results from the accumulation of beta(2)-microglobulin, primarily affecting musculoskeletal tissues.
Purpose of the Study:
- To review the diagnostic capabilities of various imaging modalities for Dialysis-related amyloidosis.
- To highlight the effectiveness of MRI and ultrasound in detecting early and specific DRA manifestations.
Main Methods:
- Review of literature on imaging findings in Dialysis-related amyloidosis.
- Comparison of plain radiography, MRI, and ultrasound for DRA detection.
Main Results:
- Plain radiography shows advanced bone erosions and cystic lesions in DRA but is insensitive to early changes.
- Magnetic resonance imaging (MRI) and ultrasound are effective in detecting amyloid deposition in periarticular soft tissues.
- These advanced imaging techniques are also valuable for evaluating spinal complications associated with DRA.
Conclusions:
- While plain radiography reveals late-stage DRA, MRI and ultrasound offer superior visualization of early and soft tissue-related changes.
- Advanced imaging modalities are crucial for comprehensive assessment and management of patients with Dialysis-related amyloidosis.