Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute liver failure.

R Q Gill1, R K Sterling

  • 1Division of Gastroenterology, Section of Hepatology and Liver Transplantation, Medical College of Virginia, Commonwealth University, Richmond, Virginia 23298-0341, USA.

Journal of Clinical Gastroenterology
|August 14, 2001
PubMed
Summary

Acute liver failure (ALF) is a severe condition with high mortality. Early recognition and referral for liver transplantation are critical for patient survival.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Psychometric properties of the PROMIS short form measures in a U.S. cohort of 961 patients with chronic hepatitis C prescribed direct acting antiviral therapy.

Alimentary pharmacology & therapeutics·2018
Same author

Chronic opioid use is associated with altered gut microbiota and predicts readmissions in patients with cirrhosis.

Alimentary pharmacology & therapeutics·2016
Same author

HCV eradication does not impact gut dysbiosis or systemic inflammation in cirrhotic patients.

Alimentary pharmacology & therapeutics·2016
Same author

Virological outcomes and treatment algorithms utilisation in observational study of patients with chronic hepatitis C treated with boceprevir or telaprevir.

Alimentary pharmacology & therapeutics·2015
Same author

Randomised clinical trial: Lactobacillus GG modulates gut microbiome, metabolome and endotoxemia in patients with cirrhosis.

Alimentary pharmacology & therapeutics·2014
Same author

Modified-orientation log to assess hepatic encephalopathy.

Alimentary pharmacology & therapeutics·2012

Area of Science:

  • Hepatology and critical care medicine.

Background:

  • Acute liver failure (ALF) is liver injury with hepatic encephalopathy.
  • Common causes include viral hepatitis, drug overdose (acetaminophen), toxins, and metabolic disorders.
  • High mortality (40-80%) is linked to complications like cerebral edema and sepsis.

Purpose of the Study:

  • To emphasize the critical importance of recognizing acute liver failure.
  • To highlight the necessity of urgent referral for liver transplantation assessment.

Main Methods:

  • Review of established definitions and etiologies of ALF.
  • Discussion of common complications and current intensive care management.
  • Evaluation of prognostic models for spontaneous recovery prediction.

Main Results:

  • Despite advances, ALF mortality remains high.
  • Supportive care and complication management are standard treatments.
  • Liver transplantation is the only definitive therapy for non-recoverable cases.

Conclusions:

  • Prompt identification of ALF is crucial.
  • Urgent referral to a transplant center is essential for evaluating transplantation eligibility.
  • Timely intervention significantly impacts patient outcomes in acute liver failure.

Related Experiment Videos