Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hepatic Encephalopathy01:29

Hepatic Encephalopathy

DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hot and cold fibrosis: The role of serum biomarkers to assess immune mechanisms and ECM-cell interactions in human fibrosis.

Journal of hepatology·2025
Same author

Expert consensus on the diagnosis and treatment of end-stage liver disease complicated by infections.

Hepatology international·2024
Same author

Major Trends in Gastroenterology and Hepatology Between 2010 and 2019: An Overview of Advances From the Past Decade Selected by the Editorial Board of The American Journal of Gastroenterology.

The American journal of gastroenterology·2020
Same author

Editorial: patient-reported outcomes in chronic HCV-a PROMISing approach to an ongoing problem.

Alimentary pharmacology & therapeutics·2018
Same author

Beta-blockers in hospitalised patients with cirrhosis and ascites: mortality and factors determining discontinuation and reinitiation.

Alimentary pharmacology & therapeutics·2017
Same author

Acute Kidney Injury in Cirrhosis: Baseline Serum Creatinine Predicts Patient Outcomes.

The American journal of gastroenterology·2017
Same journal

Letter: Interpretation of Cognitive and Clinical Outcomes in the Randomised Trial of Rifaximin for Covert Hepatic Encephalopathy.

Alimentary pharmacology & therapeutics·2026
Same journal

Editorial: Dissecting the Natural History of Recurrent Pancreatitis.

Alimentary pharmacology & therapeutics·2026
Same journal

Letter: Severity-Informed Enrichment for Recurrent Acute Pancreatitis Trials.

Alimentary pharmacology & therapeutics·2026
Same journal

Letter: HBsAg Loss After COVID-19 Vaccination: Implications for HBV Screening, Immunity Monitoring, and Health Worker Protection in LMICs. Authors' Reply.

Alimentary pharmacology & therapeutics·2026
Same journal

Editorial: Mind the Gap-Peripheral Immune Signatures of HBV Cirrhosis in an Underserved Population.

Alimentary pharmacology & therapeutics·2026
Same journal

Editorial: Fatigue in Disorders of Gut-Brain Interaction-An Important Symptom to Recognise.

Alimentary pharmacology & therapeutics·2026
See all related articles

Related Experiment Video

Updated: May 24, 2026

Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies
07:12

Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies

Published on: November 19, 2020

Modified-orientation log to assess hepatic encephalopathy.

M Salam1, S Matherly, I S Farooq

  • 1Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, USA.

Alimentary Pharmacology & Therapeutics
|February 22, 2012
PubMed
Summary
This summary is machine-generated.

The modified-orientation log (MO-log) is a reliable tool for assessing hepatic encephalopathy (HE) severity in cirrhosis patients. This new method outperforms the West-Haven criteria in predicting patient outcomes during hospitalization.

More Related Videos

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats
08:47

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats

Published on: November 8, 2018

Related Experiment Videos

Last Updated: May 24, 2026

Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies
07:12

Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies

Published on: November 19, 2020

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats
08:47

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats

Published on: November 8, 2018

Area of Science:

  • Hepatology
  • Neurology
  • Clinical Assessment

Background:

  • Subjectivity of West-Haven criteria (WHC) impacts hepatic encephalopathy (HE) evaluation.
  • New HE classification emphasizes orientation assessment.
  • Modified-orientation log (MO-log) adapted from brain injury measure (scores 0-24).

Purpose of the Study:

  • Validate MO-log for HE assessment in cirrhosis patients.
  • Compare MO-log efficacy against WHC in predicting HE outcomes.

Main Methods:

  • Administered MO-log to cirrhotic patients with/without HE.
  • Collected MO-log and WHC data, assessing changes over Day 1.
  • Analyzed outcomes: mortality, time to normal mentation, length-of-stay (LOS).
  • Performed regression analyses and measured MO-log inter-rater reliability.

Main Results:

  • MO-log showed significant negative correlation with WHC (r = -0.79, P < 0.0001).
  • Lower admission MO-logs correlated with higher mortality (P = 0.03).
  • MO-log improvement on Day 1 predicted shorter duration to normal mentation and lower mortality (P = 0.03).
  • MO-log demonstrated high inter-rater reliability (ICC = 0.991).

Conclusions:

  • Modified-orientation log (MO-log) is a valid tool for assessing HE severity.
  • MO-log is superior to WHC in predicting outcomes for hospitalized HE patients.