Related Experiment Video
Updated: Jul 25, 2026
10:02
piggyBac Transposon System Modification of Primary Human T Cells
Published on: November 5, 2012
Growth and genetic modification of human beta-cells and beta-cell precursors
G M Beattie1, A Hayek, F Levine
1Department of Pediatrics, Whittier Institute and Center for Molecular Genetics, UCSD School of Medicine, La Jolla, CA 92093, USA.
Genetic Engineering
|August 15, 2001
Abstract
No abstract available in PubMed .
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Related Concept Videos
00:49What is Genetic Engineering?
Overview
01:28Forced Transdifferentiation
Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial transdifferentiation occurs...
Artificial transdifferentiation occurs...
01:24Methods of Nuclear Reprogramming
Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.