Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

Role of Hippocampus in Memory

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

Negative and Cognitive Symptoms of Schizophrenia

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Neural correlates of out-group bias predict social impairment in patients with schizophrenia.

Schizophrenia research·2015

Same author

Abstracts of Presentations at the International Conference on Basic and Clinical Multimodal Imaging (BaCI), a Joint Conference of the International Society for Neuroimaging in Psychiatry (ISNIP), the International Society for Functional Source Imaging (ISFSI), the International Society for Bioelectromagnetism (ISBEM), the International Society for Brain Electromagnetic Topography (ISBET), and the EEG and Clinical Neuroscience Society (ECNS), in Geneva, Switzerland, September 5-8, 2013.

Clinical EEG and neuroscience·2013

Same author

The anatomy of the proximal radioulnar joint.

Journal of shoulder and elbow surgery·2012

Same author

Neural models of schizophrenia.

Dialogues in clinical neuroscience·2011

Same author

Testing models of thalamic dysfunction in schizophrenia using neuroimaging.

Journal of neural transmission (Vienna, Austria : 1996)·2005

Same author

Hippocampal neurons in schizophrenia.

Journal of neural transmission (Vienna, Austria : 1996)·2002

Search research articles

Related Experiment Video

Updated: Jul 25, 2026

Brain Imaging Investigation of the Neural Correlates of Emotional Autobiographical Recollection

Brain Imaging Investigation of the Neural Correlates of Emotional Autobiographical Recollection

Published on: August 26, 2011

Neuroimaging of declarative memory in schizophrenia.

A P Weiss¹, S Heckers

¹Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA. aweiss@partners.org

Scandinavian Journal of Psychology

|August 15, 2001

Summary

Schizophrenia is linked to impaired declarative memory due to abnormal brain connectivity. Neuroimaging reveals altered communication between the prefrontal cortex and key memory regions like the hippocampus.

More Related Videos

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Related Experiment Videos

Last Updated: Jul 25, 2026

Brain Imaging Investigation of the Neural Correlates of Emotional Autobiographical Recollection

Brain Imaging Investigation of the Neural Correlates of Emotional Autobiographical Recollection

Published on: August 26, 2011

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Area of Science:

Neuroscience
Cognitive Science
Psychiatry

Background:

Schizophrenia is a complex mental disorder.
Cognitive impairments, particularly memory deficits, are a core feature of schizophrenia.
Understanding the neural basis of these deficits is crucial for developing effective treatments.

Purpose of the Study:

To review the role of structural and functional neuroimaging in understanding schizophrenia's cognitive impairments.
To elucidate the cerebral basis for declarative memory deficits in schizophrenia.

Main Methods:

Review of structural neuroimaging studies.
Review of functional neuroimaging studies.
Analysis of studies investigating neural correlates of memory in schizophrenia.

Main Results:

Schizophrenia is associated with significant declarative memory impairment.
Abnormal connectivity between the prefrontal cortex and memory-related regions is implicated.
Key regions involved include the hippocampus, thalamus, and cerebellum.

Conclusions:

Neuroimaging has significantly advanced the understanding of schizophrenia's neural underpinnings.
Declarative memory deficits in schizophrenia stem from disrupted prefrontal connectivity to critical memory structures.
Further research into these neural pathways may inform therapeutic strategies.