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Structural analysis of chloroquine resistance reversal by imipramine analogs
A K Bhattacharjee1, D E Kyle, J L Vennerstrom
1Department of Medicinal Chemistry, Walter Reed Army Institute of Research, Washington, DC 20307-5100, USA.
Antimicrobial Agents and Chemotherapy
|August 15, 2001
Abstract:
For imipramine, desipramine, and eight analogs of these well-known drugs, an N-5-aminoalkyl substitution was a minimum but insufficient structural feature associated with chloroquine resistance reversal. Although a second distal aliphatic nitrogen atom was unnecessary for resistance reversal, the direction of the dipole moment vector was critical.