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Related Experiment Videos

Allergic rhinitis and asthma: more similarities than differences.

A G Palma-Carlos1, M Branco-Ferreira, M L Palma-Carlos

  • 1CHIUL, Imuno-Alergologia-Faculdade de Medicina de Lisboa, Portugal.

Allergie Et Immunologie
|August 17, 2001
PubMed
Summary

The nose and bronchi share a close link, with nasal issues potentially triggering asthma symptoms. Treating nasal inflammation is crucial for effective asthma management and improving overall respiratory health.

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Area of Science:

  • Immunology
  • Respiratory Medicine
  • Allergology

Background:

  • Clinical studies reveal a strong functional and immunological connection between the nose and bronchi.
  • Nasal stimulation can trigger bronchoconstriction via a rhinobronchial reflex.
  • Inflammatory mediators from the nose can be inhaled, leading to bronchial inflammation.

Purpose of the Study:

  • To explore the relationship between nasal and bronchial conditions.
  • To highlight the significance of treating rhinitis for asthma management.
  • To support the 'one airway, one disease' concept.

Main Methods:

  • Review of clinical, epidemiological, and pathophysiological studies.
  • Analysis of the impact of nasal stimulation on bronchial responses.

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  • Examination of the effects of bronchial provocation on nasal inflammation.

    • Main Results:

    • Allergic rhinitis significantly increases the risk of developing asthma.
    • A high comorbidity exists: 75% of asthmatics have rhinitis, and 20-40% of rhinitic patients have asthma.
    • Nasal inflammation can induce bronchial changes in asthmatic patients.

    Conclusions:

    • Rhinitis and asthma are common comorbidities, suggesting a unified airway disease concept.
    • Treating nasal inflammation, including rhinitis and sinusitis, is essential for controlling asthma symptoms and reducing airway hyperresponsiveness.
    • Addressing nasal inflammation is a key strategy for effective asthma control.