Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Angiogenesis factors.

M Kuwano1, J Fukushi, M Okamoto

  • 1Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka.

Internal Medicine (Tokyo, Japan)
|August 17, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prediction of pathological response to preoperative chemotherapy for pancreatic ductal adenocarcinoma using 2-[<sup>18</sup>F]-fluoro-2-deoxy-d-glucose positron-emission tomography.

Clinical radiology·2022
Same author

Image quality and radiation dose of renal perfusion CT with low-dose contrast agent: a comparison with conventional CT using a 320-row system.

Clinical radiology·2019
Same author

Clinical Outcomes of Living Liver Transplantation According to the Presence of Sarcopenia as Defined by Skeletal Muscle Mass, Hand Grip, and Gait Speed.

Transplantation proceedings·2017
Same author

Predictors of therapeutic effect of transarterial chemoembolisation using drug-eluting beads for hepatocellular carcinoma.

Clinical radiology·2017
Same author

Fatty change in moderately and poorly differentiated hepatocellular carcinoma on MRI: a possible mechanism related to decreased arterial flow.

Clinical radiology·2016
Same author

Balanced MR cholangiopancreatography with motion-sensitised driven-equilibrium (MSDE) preparation: feasibility of Gd-EOB-DTPA-enhanced biliary examination.

Clinical radiology·2016

Angiogenesis, the formation of new blood vessels, is crucial for development and disease. Understanding its complex regulation by factors like VEGF is key to treating various conditions.

Area of Science:

  • * Biomedical science, focusing on vascular biology and disease pathology.

Background:

  • * Angiogenesis, the development of new blood vessels, is a critical process in embryogenesis (vasculogenesis) and in response to physiological or pathological stimuli.
  • * Hemangioblasts and blood islands are key precursors in early vessel formation (tubulogenesis).
  • * Dysregulation of angiogenesis is implicated in numerous diseases, including cancer and ocular conditions.

Purpose of the Study:

  • * To explore the multifaceted role of angiogenesis in both normal development and pathological conditions.
  • * To highlight the significance of key molecular factors and cellular precursors in vascular development.
  • * To underscore the complex regulatory mechanisms governing angiogenesis in various diseases.

Main Methods:

  • * Review of existing literature on angiogenesis, vasculogenesis, and related molecular factors.

Related Experiment Videos

  • * Analysis of gene knockout studies involving key angiogenesis regulators such as vascular endothelial growth factor (VEGF)/VEGF receptor, ephrin-B2, and angiopoietin-1.
  • * Examination of the role of dormant factors in maintaining angiogenic homeostasis.

    • Main Results:

    • * Gene knockout studies demonstrate the essential roles of VEGF/VEGF receptor, ephrin-B2, and angiopoietin-1 in normal vessel formation.
    • * Hemangioblasts and blood islands are identified as critical early players in the angiogenesis cascade.
    • * Complex angiogenesis networks are observed in pathological conditions, indicating pleiotropic regulatory mechanisms.

    Conclusions:

    • * Angiogenesis is a fundamental biological process with significant implications for human health and disease.
    • * Precise regulation of angiogenesis by various factors is essential for normal development and tissue homeostasis.
    • * Targeting complex angiogenesis networks offers potential therapeutic strategies for diseases like cancer, ocular disorders, and inflammatory conditions.