LIS1: from cortical malformation to essential protein of cellular dynamics
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Updated: Oct 5, 2026

Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner
Published on: December 10, 2015
R J Leventer1, C Cardoso, D H Ledbetter
1Dept. of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
Abstract:
The LIS1 gene was cloned following the study of children with lissencephaly and cytogenetic abnormalities involving chromosome 17p, however, the role of the LIS1 protein in normal cortical development is not precisely defined. LIS1 is a component of evolutionarily conserved intracellular multiprotein complexes and recent literature shows that these complexes are essential, not only for neuronal migration, but they might also be fundamental components of the machinery for cell proliferation and intracellular transport.
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