Related Experiment Video
Updated: Feb 26, 2026
06:08
Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
Published on: September 22, 2023
2.7K
[Epidemiologic studies about the allergic diseases (author's transl)]
Revue Francaise Des Maladies Respiratoires
|March 1, 1979
Summary
Childhood asthma prevalence is rising in Birmingham, particularly among second-generation immigrants. Early-onset asthma and eczema are linked to specific immune responses and birth season, suggesting environmental triggers like dust mites.
Area of Science:
- Pediatric Allergy and Immunology
- Epidemiology
- Environmental Health
Context:
- Birmingham experienced a 20-year rise in childhood asthma.
- Immigrant children born in England show increased asthma prevalence compared to those born abroad.
Purpose:
- To investigate trends in childhood asthma and eczema prevalence.
- To explore associations between asthma onset, immune markers, and birth seasonality.
Summary:
- Asthma and eczema onset precedes peak allergen sensitivity.
- Elevated Immunoglobulin G4 (IgG4) levels are found in 35% of atopic children, correlating with poor response to cromoglycate and increased steroid dependency.
- Children with eczema exhibit high Immunoglobulin G4 (IgG4) and Immunoglobulin E (IgE) levels.
- A higher incidence of asthma births occurs between May and October, linked to dust mite sensitivity, not pollen or hay fever.
Impact:
- Highlights the impact of environmental factors and birthplace on childhood asthma development.
- Identifies potential biomarkers (IgG4, IgE) for asthma severity and treatment response.
- Informs public health strategies for managing pediatric respiratory conditions.
More Related Videos
Related Concept Videos
01:30Drug Toxicity: Allergic Reactions
59
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
59
01:30Allergic Reactions: Anaphylaxis
76
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
76
02:06Allergic Reactions
32.7K
Overview
32.7K
01:20Asthma: Pathogenesis and Management
1.5K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.5K
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
2.0K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
2.0K
01:26Asthma-II: Pathophysiology and Classification
4.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.7K