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Published on: July 7, 2023
Pseudophakia and polypseudophakia in the first year of life
M E Wilson1, M W Peterseim, J A Englert
1Storm Eye Institute, Department of Ophthalmology, Medical University of South Carolina, Charleston, South Carolina 29425, USA. wilsonme@musc.edu
Insights
Intraocular lens (IOL) implantation in infants is feasible, with a 25% reoperation rate in the first two years. Long-term visual acuity data requires further follow-up for this early-life procedure.
Area of Science:
- Ophthalmology
- Pediatric Ophthalmology
- Surgical Innovation
Background:
- Infantile cataracts require timely intervention for optimal visual development.
- Intraocular lens (IOL) implantation in the first year of life presents unique challenges and considerations.
- The technique of temporary polypseudophakia is explored for managing aphakia in infants.
Purpose of the Study:
- To document outcomes of intraocular lens (IOL) implantation in infants.
- To evaluate the feasibility and safety of early-life IOL implantation.
- To report on a novel approach termed temporary polypseudophakia.
Main Methods:
- Retrospective chart analysis of patients undergoing IOL implantation within the first year of life.
- Analysis of ocular growth, refractive changes, and complication rates.
- Assessment of reoperation rates and visual outcomes.
Main Results:
- Forty-seven eyes of 33 infants underwent IOL implantation (single or piggyback).
- A 23% reoperation rate for anterior segment complications was observed within the follow-up period.
- Significant refractive shifts and ocular growth were noted, with amblyopia present in some cases.
Conclusions:
- Intraocular lens (IOL) implantation in infancy is technically achievable.
- The reoperation rate is approximately 25% within the initial two years post-implantation.
- Long-term visual acuity and outcomes necessitate extended follow-up.
Purpose:
To report a consecutive series of patients undergoing intraocular lens (IOL) implantation in the first year of life. A new procedure, referred to as temporary polypseudophakia, is reported.
Methods:
A retrospective chart analysis was conducted. Ocular growth and refractive change, complications and reoperation rates, and outcomes were analyzed.
Results:
Forty-seven eyes of 33 patients underwent IOL implantation in the first year of life. Average follow-up was 22 months (range, 7 weeks to 5 years). Thirty-two eyes of 22 patients had a single IOL implanted from 12 days to 11 months of age. Fifteen eyes of 11 infants received piggyback IOLs from 16 days to 6.8 months of age. Reoperation for complications within the anterior segment of the eye was needed in 23% of all patients (22% for single IOLs, 26% for piggyback IOLs). The average first postoperative refraction after single IOL was +7.98 D and after piggyback IOL was +1.67 D. The average last postoperative refraction was +1.76 D and -4.48 D, respectively. On average, eyes grew 2.68 mm over 17.5 months of follow-up. Eight patients were old enough for Snellen visual acuity, but each had deprivation amblyopia with visual acuities from 20/85 to 5/200. Of the remaining 25 patients, 17 had central, steady, and maintained fixation in the implanted eyes.
Conclusion:
IOL implantation in infancy is technically feasible and associated with a reoperation rate of approximately 25% in the first 2 years after implantation. Further follow-up is required before meaningful visual acuity data and long-term results can be reported.
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