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Foveal ectopia in X-linked retinoschisis
M McKibbin1, A P Booth, N D George
1Leeds General Infirmary, United Kingdom. martinmckibbin@cswebmail.com
Retina (Philadelphia, Pa.)
|August 18, 2001
Summary
Foveal ectopia is common in X-linked retinoschisis (XLRS), affecting at least 30% of eyes. This finding may help diagnose XLRS and understand its development.
Area of Science:
- Ophthalmology
- Genetics
- Retinal Diseases
Background:
- X-linked retinoschisis (XLRS) is a genetic disorder affecting vision.
- The precise anatomical changes in the fovea in XLRS are not fully understood.
Purpose of the Study:
- To compare foveal center position in XLRS patients versus controls.
- To determine the frequency of foveal ectopia in XLRS.
Main Methods:
- Analyzed fundus photographs of 23 XLRS patients and 25 controls.
- Measured foveal center position relative to the optic disc.
- Calculated foveal ectopia using established definitions.
Main Results:
- Foveal ectopia was identified in 30% of XLRS eyes, compared to 0% in controls (P < 0.001).
- The foveal center in XLRS eyes was located significantly differently relative to the optic disc compared to controls.
Conclusions:
- Foveal ectopia is a frequent finding in X-linked retinoschisis.
- Foveal ectopia may serve as a diagnostic marker for XLRS.
- This anatomical deviation offers insights into the pathogenesis of XLRS.
