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Updated: Aug 9, 2026
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Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
OUTCOMES AND HEALING PROCESS OF RETINAL PIGMENT EPITHELIAL TEARS IN AMD PATIENTS: A 5-YEAR RETROSPECTIVE
Hela Sassi1, Alexandra Miere1, Hassiba Oubraham1
1Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil, Université Paris Est Créteil, France.
Retina (Philadelphia, Pa.)
|August 7, 2026
Summary
Retinal pigment epithelium (RPE) remodeling, known as tear-associated retinal pigment epithelial proliferation (TARP), occurred in half of age-related macular degeneration (AMD) eyes with RPE tears within a year. However, TARP did not improve visual outcomes over five years.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Age-Related Macular Degeneration (AMD)
Background:
- Age-related macular degeneration (AMD) is a leading cause of vision loss.
- Retinal pigment epithelium (RPE) tears are a known complication of AMD.
- Understanding RPE remodeling after tears is crucial for predicting visual outcomes.
Purpose of the Study:
- To determine the incidence of RPE remodeling after RPE tears in AMD.
- To assess the association between RPE remodeling and visual outcomes over a 5-year period.
Main Methods:
- Retrospective observational study of AMD eyes with RPE tears and ≥5 years follow-up.
- Evaluation of best-corrected visual acuity (BCVA) changes.
- Assessment of tear-associated retinal pigment epithelial proliferation (TARP) presence and onset.
Main Results:
- 54.2% of eyes developed TARP, typically within 293 days.
- RPE loss area and diameter increased significantly over 5 years.
- TARP was not associated with visual outcome, and BCVA declined in all groups.
Conclusions:
- RPE remodeling (TARP) is common after RPE tears in AMD.
- TARP does not appear to confer a visual benefit.
- Anatomical changes do not necessarily translate to improved vision in AMD with RPE tears.
