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Updated: Aug 12, 2026

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
Published on: November 24, 2021
Investigation of follicular penetration of topically applied substances
J Lademann1, N Otberg, H Richter
1Center of Experimental and Applied Cutaneous Physiology, Dermatological Clinic, Medical Faculty Charité, Humboldt University, Berlin, Germany. juergen.lademann@charite.de
Abstract:
The influence of specific follicle properties, sebum production and hair growth on the follicular penetration of topically applied substances was investigated. The behavior of follicles identified in selected skin areas of volunteers was analyzed by various tape stripping and staining methods in combination with laser scanning microscopy. Furthermore hair growth in the selected skin areas was determined. A correlation between sebum production, hair growth activity and follicular penetration was observed.
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