Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Local excision of rectal carcinoma.

M I Chorost1, N J Petrelli, M McKenna

  • 1Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.

The American Surgeon
|August 21, 2001
PubMed
Summary

Local excision of rectal adenocarcinoma has a high recurrence rate without adjuvant therapy. Salvage surgery can be effective, but adjuvant chemoradiation may reduce recurrence and improve outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

"I know this is on my chest, let's act": a qualitative study exploring self-management of acute COPD exacerbations with a sputum colour chart to reduce unnecessary antibiotic use.

NPJ primary care respiratory medicine·2024
Same author

Group B Streptococcal Management in Penicillin-allergic Pregnant Women.

Irish medical journal·2024
Same author

Association between maternal blood lipids during pregnancy and offspring growth trajectories in a predominantly macrosomic cohort: findings from the ROLO longitudinal birth cohort study.

European journal of pediatrics·2023
Same author

Group & save sampling in lumbar decompression: A review into current practice.

Journal of perioperative practice·2020
Same author

Diagnosis and treatment of a caecal mucocoele in a dog.

The Journal of small animal practice·2020
Same author

Controlling wettability of PECVD-deposited dual organosilicon/carboxylic acid films to influence DNA hybridisation assay efficiency.

Journal of materials chemistry. B·2020

Area of Science:

  • Gastroenterology
  • Surgical Oncology
  • Oncology

Background:

  • Local excision is a treatment option for rectal adenocarcinoma.
  • Adjuvant therapy's role in improving outcomes after local excision is not fully established.

Purpose of the Study:

  • To determine the recurrence rate after local excision of rectal adenocarcinoma.
  • To evaluate the salvage rate following recurrence.
  • To assess overall survival after local excision.

Main Methods:

  • Retrospective review of 31 patients with rectal adenocarcinoma treated with local excision between 1990 and 1999.
  • Exclusion of nine patients with advanced stage disease (T2 with vascular invasion or T3).
  • Analysis of 22 patients (13 T1, 9 T2) who underwent transanal excision.

Related Experiment Videos

Main Results:

  • Seven patients (32%) experienced local recurrence, all in those not receiving adjuvant chemoradiation.
  • Four patients with T1 and three with T2 tumors recurred.
  • All recurrences were salvaged by resection; four patients remain disease-free at a median follow-up of 19.5 months.

Conclusions:

  • Local excision without adjuvant therapy results in an unacceptably high local recurrence rate for rectal adenocarcinoma.
  • While salvage resection can be successful, long-term outcomes are uncertain.
  • Adjuvant chemoradiation appears to decrease recurrence rates and may become a standard treatment adjunct.