Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vaccinations01:51

Vaccinations

51.3K
Overview
51.3K
Cancer Vaccines01:30

Cancer Vaccines

990
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
990
Nose and Nasal Cavity01:24

Nose and Nasal Cavity

11.3K
The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...
11.3K
Administering Oxygen by Nasal Cannula01:29

Administering Oxygen by Nasal Cannula

2.9K
Oxygen therapy is critical to patient care, especially for those struggling with respiratory issues. This intervention increases the oxygen concentration in the lungs, enhancing the amount of oxygen transported to the body's tissues. One standard method of delivering supplemental oxygen is through a nasal cannula, a non-invasive device that provides low to medium oxygen concentrations.
Nasal Cannulas
A nasal cannula is a lightweight tube split into two prongs placed in the nostrils,...
2.9K
Oxygen Delivering System I: Nasal Cannula and Face Mask01:26

Oxygen Delivering System I: Nasal Cannula and Face Mask

1.6K
The human body requires oxygen to function, and when the natural process of respiration is hindered, external devices, including the following, are needed to help deliver this vital gas.
Nasal Cannula
A nasal cannula is a lightweight tube split at one end into two prongs and placed in the nostrils. It is typically used to deliver low to medium levels of oxygen.
Suggested flow rate: The suggested flow rate for a nasal cannula typically ranges between 1 and 6 L/min.
Oxygen percentage setting:...
1.6K
What is the Immune System?01:38

What is the Immune System?

127.2K
Overview
127.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First evidence of Kunjin strain of West Nile virus associated with saltwater crocodile (Crocodylus porosus) skin lesions.

Australian veterinary journal·2019
Same author

Ventral hernia repair outcomes predicted by a 5-item modified frailty index using NSQIP variables.

Hernia : the journal of hernias and abdominal wall surgery·2019
Same author

The effect of density on the gastric emptying of single- and multiple-unit dosage forms.

Pharmaceutical research·2013
Same author

Microviscosity and drug release from topical gel formulations.

Pharmaceutical research·2013
Same author

Thermodynamics of distribution of salicylates in semi-solid ointment bases.

Pharmaceutical research·2013
Same author

Impact of operative duration on postoperative pulmonary complications in laparoscopic versus open colectomy.

Surgical endoscopy·2013
Same journal

Silicone oil in protein drug products and its implications for formulation stability.

Advanced drug delivery reviews·2026
Same journal

Targeted delivery of proteolysis-targeting chimeras (PROTAC) and molecular glue degraders (MGD).

Advanced drug delivery reviews·2026
Same journal

Lysosome-targeting degrader delivery system: from formulation design to biomedical applications.

Advanced drug delivery reviews·2026
Same journal

Anti-PEG antibodies in nanomedicine: Mechanisms, risks, and opportunities.

Advanced drug delivery reviews·2026
Same journal

Optimizing macrophage-targeted intracellular delivery systems for safe and effective immunotherapies.

Advanced drug delivery reviews·2026
Same journal

Light-controlled CRISPR-dCas9 epigenome editing: advanced drug-delivery strategies and oncology applications.

Advanced drug delivery reviews·2026
See all related articles

Related Experiment Video

Updated: Jan 26, 2026

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo
07:33

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo

Published on: September 28, 2022

2.2K

Nasal vaccines.

S S Davis1

  • 1Institute of Pharmaceutical Sciences, University of Nottingham, Boots Science Building, Science Road, University Park, NG7 2RD, Nottingham, UK. stanley.davis@nottingham.ac.uk

Advanced Drug Delivery Reviews
|August 23, 2001
PubMed
Summary
This summary is machine-generated.

Nasal vaccination presents opportunities for preventing respiratory diseases. Intranasal administration leverages the common mucosal immune system for site-specific protection, considering formulation and physiological factors.

More Related Videos

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

11.2K
Expression and Purification of Virus-like Particles for Vaccination
06:17

Expression and Purification of Virus-like Particles for Vaccination

Published on: June 2, 2016

22.7K

Related Experiment Videos

Last Updated: Jan 26, 2026

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo
07:33

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo

Published on: September 28, 2022

2.2K
Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

11.2K
Expression and Purification of Virus-like Particles for Vaccination
06:17

Expression and Purification of Virus-like Particles for Vaccination

Published on: June 2, 2016

22.7K

Area of Science:

  • Immunology
  • Vaccinology
  • Respiratory Medicine

Background:

  • The nasal route offers a promising alternative for vaccine delivery, particularly for respiratory illnesses.
  • Understanding antigen deposition, clearance, and lymphoid tissue differences across species is crucial for effective respiratory tract vaccination.
  • The common mucosal immune system plays a key role in immune responses following intranasal administration.

Purpose of the Study:

  • To review vaccination via the respiratory tract.
  • To describe and contrast antigen deposition and clearance in the deep lung and nose.
  • To highlight the importance of species-specific lymphoid structures and the common mucosal immune system in intranasal vaccination.

Main Methods:

  • Review of existing literature on nasal vaccination and respiratory tract immunology.
  • Comparative analysis of antigen deposition and clearance mechanisms in the nasal and deep lung regions.
  • Examination of species-specific differences in respiratory tract lymphoid tissues (e.g., nose-associated lymphoid tissue, Waldeyer's ring).

Main Results:

  • Antigen deposition and clearance patterns vary between the nose and deep lung.
  • Significant differences exist in respiratory tract lymphoid structures across species, influencing immune induction.
  • Intranasal vaccination can elicit protective immune responses at both local and distant mucosal sites.

Conclusions:

  • The nasal route is a viable strategy for respiratory disease prophylaxis.
  • Effective intranasal vaccine design requires careful consideration of formulation and physiological factors like mucociliary clearance.
  • The common mucosal immune system facilitates widespread protection after intranasal antigen exposure.