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Flow-injection extraction-spectrophotometric method for the determination of ranitidine in pharmaceutical
T Pérez-Ruiz1, C Martínez-Lozano, V Tomás
1Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, 30071, Murcia, Spain. tpr@um.es
Journal of Pharmaceutical and Biomedical Analysis
|August 23, 2001
Abstract:
The spectrophotometric determination of trace amounts of ranitidine was carried out by liquid-liquid extraction using bromothymol blue with a flow system. The determination of ranitidine in the range of 1 x 10(-5) - 1 x 10(-4) mol l(-1) was possible with a sampling frequency of 40 samples h(-1). The method was satisfactorily applied to the determination of ranitidine in pharmaceutical preparations and the recovery was quantitative and no interferences from excipients were observed.