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Related Experiment Videos

Analysis of individual thyroid tablets.

J H Graham

    Journal of Pharmaceutical Sciences
    |August 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    A new spectrophotometric method accurately measures iodine in thyroid tablets, even at low concentrations. This validated assay provides reliable thyroid hormone quantification for pharmaceutical analysis.

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    Area of Science:

    • Analytical Chemistry
    • Pharmaceutical Sciences
    • Biochemistry

    Background:

    • Thyroid hormone analysis is crucial for pharmaceutical quality control.
    • Accurate quantification of iodine content in thyroid preparations is essential.
    • Existing methods may have limitations in sensitivity or sample requirements.

    Purpose of the Study:

    • To develop a sensitive and reliable assay for determining iodine content in thyroid tablets.
    • To establish a spectrophotometric method applicable to small sample masses.
    • To validate the new assay against established pharmacopeial methods.

    Main Methods:

    • Sample ignition in a closed oxygen atmosphere.
    • Redox reactions to facilitate iodine determination.

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  • Spectrophotometric quantification of iodine as the triiodide ion.

    • Main Results:

    • The developed procedure can assay samples as small as 0.033 g (0.5 gr) of thyroid.
    • The method demonstrated high sensitivity for iodine determination.
    • Results showed excellent agreement with the United States Pharmacopeia (USP) thyroid tablet assay.

    Conclusions:

    • A novel, sensitive spectrophotometric assay for thyroid tablets has been successfully developed.
    • This method offers a reliable alternative for iodine quantification in pharmaceutical thyroid preparations.
    • The assay's accuracy and sensitivity make it suitable for quality control applications.