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Updated: Oct 5, 2026
A Recovery Cardiopulmonary Bypass Model Without Transfusion or Inotropic Agents in Rats
Published on: March 23, 2018
[Superior result of ketone body ratio in normothermic cardiopulmonary bypass]
1Saitama Cardiovascular and Respiratory Center, Medical Engineering, Saitama, Japan.
Unlabelled:
Nineteen patients undergoing aortocoronary bypass surgery were divided into two groups according to the perfusion temperature, either normothermia (36 degrees C) or hypothermia (30 degrees C). The hepatic blood flow was measured at three points before, during and after cardiopulmonary bypass. Arterial and hepatic venous ketone body ratios (AKBR, HKBR) and hepatic venous saturation (ShvO2) were measured throughout the surgery.
Results:
Hepatic blood flow in both groups was identical before, during, and after the CPB. The significantly lower ShvO2 levels were observed during the CPB in the normothermic group. The both AKBR and HKBR in the hypothermic group decreased severely after the initiation of CPB (p < 0.01). However, the reduction in AKBR and HKBR was less severe in the normothermic group.
Conclusions:
Normothermic CPB provides adequate liver perfusion and results in a better hepatic metabolism than hypothermic cardiopulmonary bypass.
