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Updated: Aug 13, 2026

Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH
Published on: August 19, 2014
[Periodic variations of spontaneous chromosome aberration rate in human blood lymphocytes ]
A N Chebotarev1, N P Bochkov, L D Katosova
1Research Center for Medical Genetics, Russian Academy of Medical Sciences, Moscow, 115478 Russia.
Abstract:
Spontaneous chromosome aberration rate in human blood lymphocytes was studied using the data collected during 30 years. Seasonal variation was found. An absolute maximum of chromosome aberration rate was observed in winter and a local maximum, in summer. In spring and autumn, this value decreased. There was a statistically significant trend towards higher frequencies of aberrant metaphases during the period studied. A periodic pattern of changes in the chromosome aberration frequency was found. The data fitted a sinusoid with a period of 4.5 years.
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