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Therapy-related refractory anemia with ringed sideroblasts in chronic lymphocytic leukemia. involvement of 3q21
1Department of Hematology, Gazi University Medical School, Oyak sitesi 21, Cankaya Ankara, Turkey. erhem@med.gazi.edu.tr
Cancer Genetics and Cytogenetics
|August 25, 2001
Abstract:
Therapy-related myelodysplastic syndrome/acute myelogenous leukemia (t-MDS/AML) is extremely rare in chronic lymphocytic leukemia (CLL) despite extensive use of alkylating agents. We present a case of heavily treated CLL with resultant therapy-related refractory anemia with ringed sideroblasts (RARS). A complex cytogenetic abnormality including involvement of 3q21 was detected and to our knowledge, is the first report of a RARS case with a 3q21 abnormality.