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Quantitative genetics and mouse behavior.

J M Wehner1, R A Radcliffe, B J Bowers

  • 1Institute for Behavioral Genetics and Department of Psychology, University of Colorado, Boulder, Colorado 80309, USA. Jeanne.Wehner@Colorado.edu

Annual Review of Neuroscience
|August 25, 2001
PubMed
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Individual differences in behavior and drug responses are common. Researchers use genetically diverse mouse models to study the genetic underpinnings of these complex traits, identifying specific gene variations.

Area of Science:

  • Behavioral genetics
  • Pharmacology
  • Animal models

Background:

  • Complex behavioral and pharmacological traits exhibit quantitative variation within populations.
  • Individual differences are influenced by both environmental and genetic factors.
  • Mice are valuable models for studying the genetic basis of complex behaviors.

Purpose of the Study:

  • To investigate the genetic basis of quantitative differences in complex behaviors using mouse models.
  • To map chromosomal regions associated with behavioral variation.
  • To identify gene polymorphisms contributing to these differences.

Main Methods:

  • Utilizing genetically defined mouse populations (inbred strains, heterogeneous stocks, selected lines).
  • Applying quantitative trait loci (QTL) mapping methods.

Related Experiment Videos

  • Analyzing chromosomal regions regulating variation.

    • Main Results:

    • Documented genetic differences in complex behaviors across mouse populations.
    • Mapped chromosomal regions associated with behavioral variation.
    • Aimed at identifying specific gene polymorphisms.

    Conclusions:

    • Genetically defined mouse models are effective for dissecting the genetic architecture of complex behaviors.
    • QTL mapping is a powerful approach for localizing genes influencing quantitative traits.
    • Further research can identify specific genes and polymorphisms responsible for behavioral variation.