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Published on: May 7, 2015
Adult-to-adult live donor liver transplantation: a short-term clinicopathologic study
G Ayata1, E Pomfret, J J Pomposelli
1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Human Pathology
|August 25, 2001
Summary
Adult-to-adult live donor liver transplantation (LDLT) shows common biliary tract pathology but good survival rates. Vascular complications, though rare, can be catastrophic, impacting graft and patient outcomes.
Area of Science:
- Hepatology
- Transplantation Surgery
- Pathology
Background:
- Pediatric live donor liver transplantation (LDLT) success and cadaveric donor shortage drive adult LDLT.
- Adult LDLT is increasingly performed, necessitating evaluation of its outcomes and complications.
Purpose of the Study:
- To histologically review liver specimens from adult LDLT recipients.
- To correlate histological findings with patient outcomes and complications.
Main Methods:
- Detailed histological review of liver specimens from 9 adult LDLT recipients.
- Correlation of findings with clinical course, graft survival, and patient survival.
Main Results:
- Biliary tract pathology was observed in 5 of 9 patients, with 3 requiring intervention.
- One patient experienced graft failure due to hemorrhagic necrosis from portal hypertension.
- Two perioperative deaths occurred due to sepsis and thrombosis.
Conclusions:
- Biliary tract pathology is frequent after adult LDLT but does not impact survival.
- Rare vascular complications can lead to graft loss or death.
