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Single nucleotide polymorphisms and recombination rate in humans
1Dept of Ecology and Evolutionary Biology, University of Arizona, Tuscon 85721, USA. nachmann@email.arizona.edu
Trends in Genetics : TIG
|August 30, 2001
Abstract:
Levels of heterozygosity for single nucleotide polymorphisms vary by more than one order of magnitude in different regions of the human genome. Regional differences in the rate of recombination explain a substantial fraction of the variation in levels of nucleotide polymorphism, consistent with the widespread action of natural selection at the molecular level.