Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Single nucleotide polymorphisms and recombination rate in humans.

M W Nachman1

  • 1Dept of Ecology and Evolutionary Biology, University of Arizona, Tuscon 85721, USA. nachmann@email.arizona.edu

Trends in Genetics : TIG
|August 30, 2001
PubMed
Summary

Human genome sequencing reveals significant variation in single nucleotide polymorphism (SNP) heterozygosity across different genomic regions. Recombination rates largely explain these differences, suggesting natural selection influences molecular diversity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Specimen collection: an essential tool.

Science (New York, N.Y.)·2014
Same author

Higher differentiation among subspecies of the house mouse (Mus musculus) in genomic regions with low recombination.

Molecular ecology·2011
Same author

Why is the house mouse karyotype so variable?

Trends in ecology & evolution·2011
Same author

Reduced introgression of the Y chromosome between subspecies of the European rabbit (Oryctolagus cuniculus) in the Iberian Peninsula.

Molecular ecology·2008
Same author

The frequency of multiple paternity suggests that sperm competition is common in house mice (Mus domesticus).

Molecular ecology·2006
Same author

Local adaptation in the rock pocket mouse (Chaetodipus intermedius): natural selection and phylogenetic history of populations.

Heredity·2004

Area of Science:

  • Human Genetics
  • Molecular Biology
  • Population Genetics

Background:

  • Levels of heterozygosity for single nucleotide polymorphisms (SNPs) exhibit substantial variation across the human genome.
  • Understanding the drivers of this variation is crucial for comprehending human genetic diversity and evolutionary processes.

Purpose of the Study:

  • To investigate the relationship between recombination rates and SNP heterozygosity levels in the human genome.
  • To assess the role of natural selection in shaping patterns of molecular polymorphism.

Main Methods:

  • Analysis of genome-wide SNP data to quantify heterozygosity levels.
  • Correlation analysis between heterozygosity and regional recombination rates.
  • Inference of selective pressures based on observed polymorphism patterns.

Related Experiment Videos

Main Results:

  • SNP heterozygosity varies by over an order of magnitude across different human genomic regions.
  • Regional recombination rates account for a significant portion of the observed variation in nucleotide polymorphism.
  • The findings are consistent with the action of natural selection on molecular variation.

Conclusions:

  • Recombination rates are a major determinant of genetic diversity patterns in the human genome.
  • Natural selection plays a substantial role in shaping molecular polymorphism, impacting heterozygosity levels.
  • These results contribute to a deeper understanding of genome evolution and the forces driving genetic variation.