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Lipoxygenases and their involvement in programmed cell death.

M Maccarrone1, G Melino, A Finazzi-Agrò

  • 1Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via di Tor Vergata 135, I-00133 Rome, Italy. Maccarrone@med.uniroma2.it

Cell Death and Differentiation
|August 30, 2001
PubMed
Summary

Lipoxygenases initiate oxidative stress-induced apoptosis by dioxygenating fatty acids. This review explores their dual role in cell death pathways across animal and plant kingdoms, suggesting conserved signaling mechanisms.

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Background:

  • Lipoxygenases (LOX) are enzymes catalyzing the dioxygenation of unsaturated fatty acids.
  • This process initiates lipoperoxidation and the synthesis of signaling molecules, impacting cellular structure and metabolism.
  • LOX enzymes are implicated in various pathophysiological conditions.

Purpose of the Study:

  • To review the characteristics of the lipoxygenase enzyme family.
  • To examine the involvement of LOX in initiating oxidative stress-induced apoptosis.
  • To discuss the role of LOX activation in animal and plant cell apoptosis.

Main Methods:

  • Literature review of studies on lipoxygenases and apoptosis.
  • Analysis of research on LOX activity in different cell types and species.

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  • Synthesis of findings regarding signal transduction pathways in apoptosis.

    • Main Results:

    • Lipoxygenases can exhibit both pro-apoptotic and anti-apoptotic effects.
    • Pro-apoptotic effects are linked to LOX activity and hydroperoxide production.
    • Evidence suggests a conserved apoptosis signal transduction pathway involving LOX across kingdoms.

    Conclusions:

    • Lipoxygenase activation plays a critical role in oxidative stress-induced apoptosis.
    • A common evolutionary conserved pathway for LOX-mediated cell death exists in animals and plants.
    • Further research is needed to fully elucidate the dual role of LOX in apoptosis.