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Photocontact dermatitis to ketoprofen.
M Sugiyama1, T Nakada, H Hosaka
1Department of Dermatology, Showa University School of Medicine, Tokyo, Japan.
Summary
Photocontact dermatitis can occur from topical ketoprofen, causing itchy rashes. Photopatch testing confirmed reactions to ketoprofen and other nonsteroidal anti-inflammatory drugs, highlighting application site risks.
Area of Science:
- Dermatology
- Photodermatology
Background:
- Topical nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain relief.
- Photocontact dermatitis is a photosensitive skin reaction to certain chemicals.
Observation:
- A 19-year-old woman presented with a 3-day history of pruritic lesions on her right forearm.
- Examination revealed a dark reddish, edematous, and papular lesion measuring 105 x 46 mm.
Findings:
- Photopatch testing showed positive reactions to ketoprofen (as-is and 1% in petrolatum).
- Reactions were also observed with suprofen 1% and tiaprofenic acid 1% in petrolatum.
- This indicates cross-reactivity among certain topical NSAIDs.
Implications:
- Clinicians should consider photocontact dermatitis when evaluating skin reactions to topical NSAIDs.
- Awareness of potential photosensitization is crucial, especially concerning application sites.
- Further investigation into NSAID-induced photosensitivity is warranted.