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Updated: Aug 3, 2026
08:25
Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
Published on: September 26, 2022
Generalized eczematous contact dermatitis from cocobolo wood
Anna D Guanche1, Steven Prawer
1Department of Dermatology, University of Minnesota, Minneapolis, MN 55455, USA.
Summary
Cocobolo wood (Dalbergia retusa) can cause delayed hypersensitivity reactions. Patch testing with wood shavings and sawdust diagnosed the allergy, leading to symptom resolution upon avoidance.
Area of Science:
- Dermatology
- Occupational Health
- Toxicology
Background:
- Cocobolo wood (Dalbergia retusa) is known for rare delayed hypersensitivity reactions.
- Occupational exposure in furniture makers presents a risk.
- Previous cases are infrequently reported.
Observation:
- A 53-year-old furniture maker developed erythroderma-like symptoms after cocobolo sawdust exposure.
- Standard patch testing was negative.
- Specific allergen (obtusaquinone) was unavailable.
Findings:
- The patient showed a strong positive reaction (+++) to cocobolo wood shavings and sawdust via patch testing.
- This diagnosis was achieved without the purified chemical allergen.
- Avoidance of cocobolo wood led to symptom resolution.
Implications:
- Patch testing with crude wood materials is effective for diagnosing cocobolo allergy.
- Highlights the importance of occupational wood dust exposure assessment.
- Emphasizes successful management through allergen avoidance.
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