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[Co-administration of histamine H1 antagonist and oral anticoagulants]

F J García Callejo, M M Velert Vila, M Marco Sanz

    Acta Otorrinolaringologica Espanola
    |August 31, 2001
    PubMed

    Indications for oral anticoagulation and antihistamine H1 antagonists therapies are increasingly. So, it is easy to find individuals who need both treatments. The unknowledgement about possible interferences of antihistamines over acenocumarin often makes to avoid them at the same time. A review on a population receiving anticoagulation on a Therapeutic Center allowed us to verify disorders secondary to the association of antihistamines into their therapeutic scheme. Loratadine, ebastine and cetirizine show similar records of interaction into acenocumarin pharmacokinetics, probably due to a liver enzymatic induction on the anticoagulant drug, producing a decrease on INR values in which anticoagulation is measured. This could make necessary to increase temporally acenocumarin dose. During coadministration no thromboembolic event nor bleeding were registered.

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