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Related Experiment Videos

Self-poisoning with Colchicum autumnale L. flowers.

V C Danel1, J F Wiart, G A Hardy

  • 1Département Pluridisciplinaire de Médecine, Centre Hospitalier Universitaire, Grenoble, France. VDanel@chu-grenoble.fr

Journal of Toxicology. Clinical Toxicology
|August 31, 2001
PubMed
Summary

A man experienced severe symptoms after ingesting autumn crocus (Colchicum autumnale L.) flowers. Toxicological analysis confirmed colchicine poisoning, highlighting the plant's toxicity and the need for supportive care in such cases.

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Area of Science:

  • Toxicology
  • Pharmacology
  • Botany

Background:

  • Colchicum autumnale L. (autumn crocus) is a plant known for its toxic properties.
  • Ingestion of autumn crocus can lead to significant gastrointestinal and systemic symptoms.
  • Accurate toxicological confirmation is crucial for managing plant-induced poisonings.

Observation:

  • A 44-year-old male presented with nausea, vomiting, and abdominal pain approximately 2 hours post-ingestion of 40 Colchicum autumnale flowers.
  • Diarrhea was observed 14 hours after ingestion; however, hematological values remained within normal limits.
  • The patient's intoxication was confirmed via high-performance liquid chromatography-mass spectrometry (HPLC-MS).

Findings:

  • Maximal plasma colchicine concentration was 4.34 ng/mL at 13 hours post-ingestion.

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  • Maximal erythrocyte colchicine concentration reached 5.43 ng/mL at 16 hours post-ingestion.
  • Supportive treatment was administered, leading to a favorable outcome for the patient.

    • Implications:

    • This case underscores the potent toxicity of Colchicum autumnale L. and the importance of prompt medical evaluation.
    • Confirmed toxicological analysis aids in understanding colchicine pharmacokinetics during poisoning events.
    • Effective supportive care can lead to positive outcomes even in symptomatic cases of autumn crocus poisoning.