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Evolution of anti-HIV drug candidates. Part 2: Diaryltriazine (DATA) analogues
D W Ludovici1, R W Kavash, M J Kukla
1Janssen Research Foundation, Welsh and McKean Roads, Spring House, PA 19477, USA.
Bioorganic & Medicinal Chemistry Letters
|August 31, 2001
Abstract:
A synthesis program directed toward improving the stability of imidoyl thiourea based non-nucleoside reverse transcriptase inhibitors (NNRTIs) led to the discovery of diaryltriazines (DATAs), a new class of potent NNRTIs. The synthesis and anti-HIV structure-activity relationship (SAR) studies of a series of DATA derivatives are described.