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Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues
D W Ludovici1, B L De Corte, M J Kukla
1Janssen Research Foundation, Welsh and McKean Roads, Spring House, PA 19477, USA.
Bioorganic & Medicinal Chemistry Letters
|August 31, 2001
Abstract:
The synthesis and anti-HIV-1 activity of a series of diarylpyrimidines (DAPYs) are described. Several members of this novel class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) are extremely potent against both wild-type and a panel of clinically significant single- and double-mutant strains of HIV-1.