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Vinyl sulfonium as novel proteolytic enzyme inhibitor
1Department of Chemistry and School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4630, USA.
Bioorganic & Medicinal Chemistry Letters
|August 31, 2001
Abstract:
Vinyl sulfoniums were synthesized from vinyl sulfides by methylation, and inhibited the proteolytic enzyme papain. Inhibition studies suggest a mechanism by which the vinyl sulfonium inhibitor covalently and irreversibly modifies the enzyme.