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Related Experiment Videos

Radiation-induced haemorrhagic cystitis.

J P Crew1, C R Jephcott, J M Reynard

  • 1Department of Urology, Churchill Hospital, Oxford, UK. jeremy@crew35.freeserve.co.uk

European Urology
|August 31, 2001
PubMed
Summary
This summary is machine-generated.

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Radiation-induced hemorrhagic cystitis is rare but serious. Early, aggressive treatment is recommended due to limited effective options for this progressive condition.

Area of Science:

  • Urology
  • Radiation Oncology

Background:

  • Radiation-induced hemorrhagic cystitis (RIHC) is a potential complication of pelvic radiotherapy.
  • While relatively rare, RIHC can be relentlessly progressive and difficult to manage.

Purpose of the Study:

  • To review the current literature on the frequency and management of severe hemorrhagic radiation-induced cystitis.

Main Methods:

  • A comprehensive Medline search was conducted from 1966 to 1999.
  • 309 English-language articles were identified and their abstracts and full texts reviewed.

Main Results:

  • Severe hemorrhagic cystitis occurs in less than 5% of patients post-pelvic irradiation, with incidence increasing over time.
  • Treatment options are varied and suboptimal, including bladder irrigation, cystodiathermy, intravesical agents, hyperbaric oxygen, embolization, diversion, and cystectomy.

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  • No single management strategy is universally successful, often necessitating a stepwise increase in treatment intensity.

    • Conclusions:

    • Existing literature on RIHC is largely retrospective with small patient cohorts and diverse treatment modalities.
    • The lack of randomized controlled trials prevents definitive management guidelines.
    • Early and aggressive treatment is likely warranted for patients with radiation-induced hemorrhagic cystitis.