Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Choreographing mRNA biogenesis.

C N Cole

    Nature Genetics
    |August 31, 2001
    PubMed
    Summary
    This summary is machine-generated.

    Eukaryotic messenger RNA (mRNA) biogenesis involves precise post-transcriptional processing and export. Packaging proteins associate with RNA polymerase II during transcription, suggesting coupled mRNA production and export.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Comparative analysis of the effects of dorzolamide and latanoprost on ocular hemodynamics in normal tension glaucoma patients.

    European journal of ophthalmology·2003
    Same author

    Coupling of termination, 3' processing, and mRNA export.

    Molecular and cellular biology·2002
    Same author

    mRNA export: the long and winding road.

    Nature cell biology·2000
    Same author

    Rat8p/Dbp5p is a shuttling transport factor that interacts with Rat7p/Nup159p and Gle1p and suppresses the mRNA export defect of xpo1-1 cells.

    The EMBO journal·1999
    Same author

    Functional characterization of a Nup159p-containing nuclear pore subcomplex.

    Molecular biology of the cell·1998
    Same author

    Nucleocytoplasmic transport: driving and directing transport.

    Current biology : CB·1998
    Same journal

    Lineage tracing from cellular heritage to disease destiny.

    Nature genetics·2026
    Same journal

    Multiomics analysis of primary metabolism reveals the genetic basis of nitrogen partitioning modulated by ZmAVT1A-1 in maize.

    Nature genetics·2026
    Same journal

    No evidence of immunosurveillance in mutation-hotspot-driven clonal hematopoiesis.

    Nature genetics·2026
    Same journal

    Near-perfect genome sequencing in medical genetics.

    Nature genetics·2026
    Same journal

    Three decades of cancer genetics.

    Nature genetics·2026
    Same journal

    Advances and challenges of splicing prediction with AI.

    Nature genetics·2026
    See all related articles

    Area of Science:

    • Molecular Biology
    • Gene Expression
    • RNA Processing

    Background:

    • Eukaryotic messenger RNA (mRNA) biogenesis necessitates accurate post-transcriptional modifications before export.
    • RNA processing factors interact with RNA polymerase II during transcription elongation.
    • mRNA export involves complexes of RNA-binding proteins and other factors.

    Discussion:

    • Recent findings reveal that mRNA packaging proteins also associate with RNA polymerase II during transcription.
    • This association suggests a mechanistic link between mRNA synthesis and its export machinery.

    Key Insights:

    • Coordination between mRNA processing, packaging, and export is crucial for functional mRNA.
    • RNA polymerase II serves as a platform for integrating transcription with mRNA maturation and export.

    Related Experiment Videos

    Outlook:

    • Further research can elucidate the precise mechanisms of this coupling.
    • Understanding this process may reveal new targets for regulating gene expression.